The Selecao currently top the South American qualification group with nine points, while Uruguay are fourth in the section, having picked up six points from their opening three fixtures.
Uruguay started their World Cup qualification campaign with a 2-1 victory over Chile on October 8 but then disappointingly suffered a 4-2 defeat to Ecuador in their second game five days later.
There was a degree of pressure on La Celeste heading into their clash with Colombia last Friday,
but an impressive performance saw them run out 3-0 winners to move onto six points in the section.
Brazil, meanwhile, will enter this match off the back of a 1-0 win over Venezuela, with Roberto Firmino coming up with the only goal of the contest in the 67th minute.
Tite’s side were far from convincing in Sao Paulo but managed to pick up another three points to leave them top of the section, two points clear of second-placed Argentina.
Brazil opened their qualification campaign with a 5-0 win over Bolivia on October 10 before recording a 4-2 victory away to Peru four days later, and they will certainly be looking to top the group.
As mentioned, they have dominated the recent meetings with Uruguay, but the fact that the injured Neymar is not available for Brazil will certainly hand the home side confidence.
However, the trio of Firmino, Gabriel Jesus and Richarlison could be just enough firepower to record a win.
In the same vein, Selecao will have to be wary of the duo of Cavani and Suarez who have shown on multiple occasions that they can decide a game.
It might not be easy but Brazil are expected to win this one and continue their perfect start to the World Cup qualifiers.
